Babban-tsarki shark chondroitin sulfate shine mabuɗin sinadari don kula da lafiyar haɗin gwiwa
Chondroitin sulfate (CS) wani muhimmin glycosaminoglycan ne wanda ke da alaƙa da haɗin gwiwa tare da sunadaran don samar da proteoglycans.An rarraba shi sosai a cikin matrix extracellular da farfajiyar tantanin halitta na kyallen jikin dabba, kuma muhimmin abu ne na kayan haɗin dabba, wanda ya fi yawa a cikin guringuntsi.Asalin tsarin chondroitin sulfate an kafa shi ta hanyar maye gurbin D-glucuronic acid da N-acetylgalactosamine ta hanyar haɗin gwiwar glycosidic, waɗanda ke da alaƙa da ainihin ɓangaren furotin don samar da hadadden tsarin proteoglycan.
Chondroitin sulfate da aka samo daga Shark yana ɗaya daga cikinsu, wanda shine sinadarin mucopolysaccharide acid wanda aka shirya daga nama na guringuntsi na shark.Ya bayyana a matsayin fari ko fari-kamar foda, babu wari, dandano mai tsaka.Chondroitin shark sulfate yana ɗaya daga cikin manyan abubuwan haɗin haɗin nama na mammalian, kuma ana samunsa sosai a cikin guringuntsi, kashi, tendons, ligaments, sarcolemma, da bangon jirgin jini.
Yana aiki azaman riƙewa da tallafi a cikin guringuntsi na articular.Matsakaicin cin abinci na chondroitin sulfate zai iya taimakawa wajen kula da nama na guringuntsi, rage kumburi da zafi, inganta aikin haɗin gwiwa, kuma yana da babban aminci.Ana amfani da shi sau da yawa tare da glucosamine, haɗin haɗin gwiwa wanda a asibiti yana inganta matsakaici zuwa zafi mai tsanani a cikin osteoarthritis kuma yana ƙarfafa sabon collagen da proteoglycans a cikin chondrocytes.
| Sunan samfur | Shark Chondroitin Sulfate Soidum |
| Asalin | Shark asalin |
| Matsayin inganci | USP40 Standard |
| Bayyanar | Fari zuwa kashe farin foda |
| Lambar CAS | 9082-07-9 |
| Tsarin samarwa | enzymatic hydrolysis tsari |
| Abubuwan da ke cikin Sunadaran | ≥ 90% ta CPC |
| Asara akan bushewa | ≤10% |
| Abubuwan da ke cikin Sunadaran | ≤6.0% |
| Aiki | Taimakon lafiya na haɗin gwiwa, guringuntsi da lafiyar ƙashi |
| Aikace-aikace | Kariyar abinci a cikin Tablet, Capsules, ko Foda |
| Halal Certificate | Ee, Halal Tabbaci |
| Matsayin GMP | NSF-GMP |
| Takaddar Lafiya | Ee, ana samun takardar shaidar lafiya don manufar sharewa ta al'ada |
| Rayuwar Rayuwa | Watanni 24 daga ranar samarwa |
| Shiryawa | 25KG/Drum, Packing na ciki: Jakunkuna na PE sau biyu, Packing na waje: Drum Takarda |
| ITEM | BAYANI | HANYAR JARRABAWA |
| Bayyanar | Kashe-fari crystalline foda | Na gani |
| Ganewa | Samfurin ya tabbatar da ɗakin karatu | By NIR Spectrometer |
| Bakan shayarwar infrared na samfurin yakamata ya nuna maxima kawai a tsawon tsayin raƙuman ruwa kamar na chondroitin sulfate sodium WS. | By FTIR Spectrometer | |
| Abubuwan da aka haɗa Disaccharides: Ragon amsa kololuwa zuwa △DI-4S zuwa △DI-6S bai gaza 1.0 ba. | Enzymatic HPLC | |
| Juyawar gani: Haɗu da buƙatun jujjuyawar gani, takamaiman juyi a takamaiman gwaje-gwaje | USP781S | |
| Assay (Odb) | 90% -105% | HPLC |
| Asara Kan bushewa | <12% | Saukewa: USP731 |
| Protein | <6% | USP |
| Ph (1% H2o Magani) | 4.0-7.0 | USP791 |
| Takamaiman Juyawa | -20° ~ -30° | USP781S |
| Rago Akan Ingition (Bushe Base) | 20% -30% | USP281 |
| Ragowar Halin Halitta | NMT0.5% | USP467 |
| Sulfate | ≤0.24% | USP221 |
| Chloride | ≤0.5% | USP221 |
| Tsara (5% H2o Magani) | <0.35@420nm | USP38 |
| Electrophoretic Tsabta | NMT2.0% | Saukewa: USP726 |
| Iyakar babu takamaiman disaccharides | 10% | Enzymatic HPLC |
| Karfe masu nauyi | ≤10 PPM | ICP-MS |
| Jimlar Ƙididdigar Faranti | ≤1000cfu/g | USP2021 |
| Yisti & Mold | ≤100cfu/g | USP2021 |
| Salmonella | Babu | USP2022 |
| E.Coli | Babu | USP2022 |
| Staphylococcus Aureus | Babu | USP2022 |
| Girman Barbashi | Keɓance bisa ga buƙatun ku | A cikin Gida |
| Yawan yawa | 0.55g/ml | A cikin Gida |
Na farko, chondroitin sulfate shine glycosaminoglycan wanda aka samo shi sosai akan matrix extracellular na kyallen takarda.A cikin kashi, an fi samun shi a cikin mahallin chondrocytes kuma muhimmin abu ne na matrix na waje na guringuntsi.Abun yana taimaka wa guringuntsi ya sami ruwa da abinci mai gina jiki, don haka kiyaye guringuntsi mai laushi da na roba, kuma yana taimakawa wajen kula da aikin yau da kullun na gidajen abinci.
Abu na biyu, tasirin ilimin lissafi na chondroitin sulfate yana da mahimmanci musamman ga guringuntsi na articular.Zai iya ɗaure kwayoyin ruwa, shayar da kwayoyin ruwa a cikin kwayoyin proteoglycan, ya karu da guringuntsi da kuma ƙara yawan ruwan synovial a cikin rami na haɗin gwiwa, mai mai da goyan bayan haɗin gwiwa.Ta wannan hanyar, haɗin gwiwa zai iya rage raguwa da tasiri lokacin motsi, don haka haɗin gwiwa zai iya motsawa cikin 'yanci.
A ƙarshe, chondroitin sulfate kuma yana aiki a aikin injiniya na nama.Masu binciken sun shirya hadaddiyar hydrogels dangane da chondroitin sulfate, wanda ke daure ion inorganic da kansa da kuma motsa jikin kwayoyin halitta, don haka yana haɓaka ƙarfin sake farfadowa na ƙasusuwa.Wannan yana da mahimman aikace-aikace don aikin tiyata na asibiti na asibiti kamar gyaran lahani na kashi da gyaran kashi.
1. Inganta lafiyar haɗin gwiwa: Chondroitin sulfate yana daya daga cikin manyan abubuwan da ke cikin guringuntsi na articular, wanda zai iya taimakawa guringuntsi don kula da elasticity da ruwa, don haka kula da aikin yau da kullum na haɗin gwiwa.Ta hanyar haɓakawa tare da chondroitin sulfate, zai iya inganta gyaran gyare-gyare da sake farfadowa na guringuntsi na articular, don haka rage jinkirin aikin haɗin gwiwa.
2. Rage ciwon haɗin gwiwa: chondroitin sulfate zai iya rage amsawar kumburi a cikin haɗin gwiwa, rage haɓakar synovium na haɗin gwiwa, sannan kuma rage ciwon haɗin gwiwa.Wannan yana da tasiri mai mahimmanci na jin zafi ga marasa lafiya da cututtukan haɗin gwiwa irin su arthritis.
3. Inganta motsi na haɗin gwiwa: Chondroitin sulfate yana inganta motsi da sassauci na haɗin gwiwa ta hanyar haɓaka lubrication na haɗin gwiwa da rage haɗin gwiwa.Wannan yana sa haɗin gwiwa ya zama mai santsi yayin motsi, rage rashin jin daɗi da ke haifar da haɗin gwiwa ko ƙayyadaddun motsi.
4. Kare guringuntsin guringuntsi: Chondroitin sulfate na iya hana lalatawar guringuntsi, da haɓaka haɓakawa da ɓoyewar ƙwayar cuta, ta yadda za'a taka rawa wajen kare guringuntsi.Wannan yana taimakawa wajen jinkirta tsarin tsufa na haɗin gwiwa da lalata.
1. Warkar da raunuka da gyaran fata: Chondroitin sulfate yana taka muhimmiyar rawa a cikin tsarin warkar da rauni.Zai iya inganta haɓakawa da gyaran gyare-gyare na ƙwayar rauni, inganta haɓakawa da ƙumburi na fata, da kuma taimakawa wajen rage tabo.Saboda haka, chondroitin sulfate yana da yuwuwar aikace-aikace a cikin hanyoyin tiyata, ƙona jiyya da gyaran fata.
2. Masana'antar kayan shafawa: Saboda kyawawan kaddarorin sa masu laushi da tasirin tsufa, ana kuma amfani da chondroitin sulfate a cikin masana'antar kayan kwalliya.Ana iya ƙarawa zuwa kayan kula da fata a matsayin kayan aiki mai laushi, yana taimakawa wajen kula da ma'auni na danshi na fata da inganta elasticity na fata da sheki.Bugu da kari, chondroitin sulfate kuma na iya hana samar da radicals kyauta, rage saurin tsufa na fata, kuma yana sa fata karami da lafiya.
3. Injiniyan nama da magani na farfadowa: A fagen aikin injiniya na nama da kuma maganin farfadowa, ana amfani da chondroitin sulfate a matsayin wani ɓangare na gina kayan stent na biomimetic.Ana iya haɗa shi tare da sauran abubuwan halitta don samar da ɓangarorin tare da takamaiman tsari da ayyuka don gyara ko maye gurbin kyallen takarda da gabobin da suka lalace.Kwayoyin halitta da bioactivity na chondroitin sulfate sun sa ya zama dan takara mai mahimmanci a fagen aikin injiniya na nama.
4. Tasirin Antitumor: A cikin 'yan shekarun nan, binciken ya gano cewa chondroitin sulfate kuma yana da yiwuwar antitumor.Zai iya hana ƙaddamarwar ƙwayar cuta da ci gaba ta hanyar daidaita tsarin girma, bambance-bambance da tsarin apoptotic na ƙwayoyin tumor.Kodayake binciken da ya dace har yanzu yana cikin mataki na farko, ana sa ran yiwuwar aikace-aikacen chondroitin sulfate a fagen maganin ƙwayar cuta.
Chondroitin sulfate da glucosamine sulfate ba iri ɗaya bane.Akwai wasu bambance-bambance a cikin tsarin su, amfani da tsarin aikin su.
Chondroitin sulfate shine glycosaminoglycan tare da nau'ikan ayyukan ilimin halitta, gami da sarrafa lipid da tasirin kumburi.An yi amfani da shi sosai a cikin maganin osteoarthritis kuma yana iya rage masu shiga tsakani da kuma matakai na apoptotic, yayin da lokaci guda ya rage samar da cytokines mai kumburi, iNOS da MMPs.Bugu da ƙari, chondroitin sulfate kuma yana taka muhimmiyar rawa wajen karewa da gyaran gyare-gyare na guringuntsi, yana taimakawa guringuntsi don tsayayya da damuwa a ƙarƙashin yanayi daban-daban ta hanyar yin juriya da nama.
Kuma glucosamine sulfate wani muhimmin sinadari ne, wanda aka fi amfani da shi wajen yin rigakafi da magance cututtuka daban-daban na osteoarthritis, kamar haɗin gwiwa gwiwa da haɗin gwiwa.Yana aiki a kan guringuntsi na articular, ta hanyar ƙarfafa chondrocytes don samar da proteoglycans tare da tsarin polysome na al'ada, inganta ƙarfin gyaran gyare-gyare na chondrocytes, hana lalacewar guringuntsi enzymes irin su collagenase da phospholipase A2, kuma zai iya hana samar da superoxidized free radicals a lalace sel, don haka jinkirta. tsarin pathological na osteoarthritis da ci gaba da cutar, inganta aikin haɗin gwiwa, rage zafi.
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